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KMID : 0043319890120040243
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Archives of Pharmacal Research
1989 Volume.12 No. 4 p.243 ~ p.248
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Inhibitory Effects of B-HT 920 on Gastric Acid Secretion Induced by Vagal Stimulation in Rat
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Hong SC
Park MS/Chung JK/Kang MH/Choi SK/Kim MW
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Abstract
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Effects of B-HT 920 on the vagally stimulated gastric acid secretion were studied in anesthetized and gastric fistula rats. When the gastric acid secretion was increased by stimulation of the vagus nerve, B-HT 920 significantly inhibited the vagally induced gastric acid secretion. This inhibitory effect of B-HT 920 was partially attenuated by prazosin, alpha1-adrenoceptor antagonist and virtually abolished by yohimbine, alpha2-adrenoceptor antagonist. On the other hand, when the gastric acid secretion was increased by the infusion of bethanechol, a muscarinic parasympathetic stimulant, B-HT 920 had no effect on the bethanechol-induced gastric acid secretion. These results suggest that B-HT 920 inhibits vagally induced gastric acid secretion by activation of presynaptic alpha-adrenoceptors located on the vagally stimulated pathways in the gastric wall and this effect of B-HT 920 is more related to alpha2-adrenoceptors than alpha1-adrenoceptors.
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